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SAN FRANCISCO Air Jordan Retro For Sale Womens , Sept. 23 (Xinhua) -- Researchers in the United States and Germany have discovered a part of protein molecules that could be key to find how proteins interact with each other inside living cells to carry out specialized functions.

Named by the researchers as "add-ons," because they work the way that computer software add-ons customize a web interface with a user, the tiny bits of molecular material on the outer edges of the protein interface are found to be able to customize what a protein can do.

Proteins are known to have an interface region where they connect with other proteins. However, before the new findings published in the Proceedings of the National Academy of Sciences, or PNAS Air Jordan Shoes For Sale Womens , it was not clear how key proteins are able to find each other within a cellular environment that may contain tens of thousands of other proteins.

The researchers at the Ohio State University in the United States and the University of Regensburg in Germany experimented with live bacteria, determined that in the organism Bacillus subtilis, or B. subtilis, in which a unique interface add-on is missing, bacteria colonies grew 80 percent less under certain conditions. The reason for this was that the missing interface add-on led to un-healthy cross-interactions of proteins in the B. subtilis cells.

The University of Regensburg team Air Jordan For Sale Womens , led by computational biologist Rainer Merkl and protein biochemist Reinhard Sterner, analyzed the protein sequences derived from more than 15,000 bacterial and archaeal genomes on a large computer cluster, sorted proteins that shared common evolutionary ancestors into a kind of family tree, and compared individual proteins to their protein "relatives Jordan Retro For Sale Womens ," thus leading them to spot interface structures that were present in some proteins but missing in others.

The Ohio State team then used native mass spectrometry to detect how the presence and absence of add-ons influenced the ability of proteins to interact with each other.

"We're really pleased that our native mass spectrometry technology could help identify the role of these interface 'add-ons' - a way for a protein to find its critical partner protein even in a crowded cellular environment with similar structures present," Vicki Wysocki, director of the Campus Chemical Instrument Center at Ohio State, was quoted as saying in a news release.

It is difficult to overstate the importance of proteins to life as we know it, according to the researchers. Enzymes are proteins that enable chemical reactions in cells; antibodies are proteins that bind to foreign invaders in the body. The list goes on to include thousands of critical functions. In most cases Jordan Shoes For Sale Womens , proteins have to connect to each other and form groups called protein complexes to perform diverse tasks.

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ERYMANTHOS, Greece, Oct. 17 (Xinhua) -- More than 100 ultra trail runners from eight countries started their 100-mile (about 161 km) journey Friday across the northern Greek mountain of Rodopi.

Officials from the Rodopi Ultra Trail Air Jordan Retro For Sale Websites , a NGO which has been organizing the annual Rodopi Advendurun 100 miles (ROUT) since 2010, said 115 runners beat the darkness at 6 am from the forest village of Erymanthos, about 700 km northeast of Athens. While most adventures are from Greece, 13 foreign runners also stood behind the start line this year.

ROUT is a tough adventure footrace for experienced runners who compete in semi-autonomy conditions running along abandoned paths and trails through the Rodopi Mountains National Park.

Organizers said ROUT is a new approach to trail running races, introducing a new vision on the ultras Air Jordan Shoes For Sale Websites , the adventure running, by putting athletes and their skills in a serious challenge, and assessing their experience gained by long practice of the sport.

ROUT is calling only experienced trail runners, requiring their maximum of physical and mental endurance.

Runners are expected to complete the 100 miles race, including 8000 meters of positive altitude change Air Jordan For Sale Websites , within 40 hours this year. The past record of ROUT was made by Greek runner Nikolaso Petropoulos, who completed the race in 2013 in 23 hours 19 minutes and 11 seconds. Petropoulos is also competing this year's 5th ROUT anniversary race.

Among this year's runners are also three women.


Lionel Messi will be working "full time" to shake off the hamstring injury sustained on Sunday that will sideline him for six to eight weeks, Barcelona's Argentine World Player of the Year said on Tuesday.

In his first public remarks since he was forced off early in Barca's 4-1 La Liga win at Real Betis, Messi said his priority was to return as soon as possible so he could contribute to the Spanish champions' quest for silverware.

"As many of you know, over the next few weeks I will be working full time on the recovery from this latest injury Jordan Retro For Sale Websites ," Messi said on his Facebook page.

"For me it is a pity not to be able to play with my team right now," added the 26-year-old.

"Now the most important thing is to recover well so I can help my team mates and reward all the support you've given to me in the best way I know how to do, playing football."

Messi was substituted in the 19th minute in Seville after pulling up following a sprint for possession and a tangle wit.

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